The findings have the potential to pave the way for new disease-modifying treatments for patients with Parkinson’s disease. A study published in Nature Communications by Beth Israel Deaconess Medical Center (BIDMC) investigators provides new insights into cellular mechanisms in Parkinson's disease

This study reveals that inhibiting a specific enzyme, USP30, in a mouse model can protect dopamine-producing neurons. This finding halts the disease’s progression and opens the door to new therapeutic possibilities for the 10 million people affected by Parkinson’s worldwide.

DOI: 10.1038/s41467-023-42876-1

https://www.nature.com/articles/s41467-023-42876-1

  • SocialMediaRefugee@lemmy.world
    2·
    8 months ago

    Related article: https://www.frontiersin.org/articles/10.3389/fphar.2022.851654/full

    Best I can deduce USP30 is in the mitochondrial wall and its function is to regulate mitochondrial apoptosis.

    “At the cellular level, several studies provide evidence for the pivotal role of USP30 involved in mitochondrial cell death and apoptosis. Mitochondria are fundamental in the orchestration of cell death pathways as they play a central role in energy production and metabolism.”