It’s a remix of the foundation, understand why they did it because otherwise they’d have to switch of the cast every few episodes. The series is set up to make people that didn’t read the books like it and I personally think a lot of what they did makes sense. Some of the changes are good, some are bad, all unfaithful but given how hard it is to put this book on screen I can see why.
I think this is it. Posting is reinforced by getting feedback on posts, both up votes and comments
Yeah, I like that setting so much that I read all my posts dimmed.
The thing is I can never see an image in the feed without it being dimmed since it’s read as soon as I expand the post.
So I’m thinking marking things as read when it’s scrolled out of view is better and also after unexpanding.
I was in denial about being autistic for around a decade after I first had suspicion because of exactly the reasoning you provide.
To provide some insight to my experience is that I had to manually decode all the non-verbal communication with logic while keeping track of the verbal stuff and monitoring my own expression back when I was masking. That shit is exhausting. Masking isn’t just picking a personality to wear based on the occasion, it’s doing that while it doesn’t come naturally and consciously tweaking behavior. Jokes on us, we give of the uncanny valley vibes when do that because it “feels off”.
If there’s something loud around me I will intensely try to hear what people say to me but I just can’t because the surrounding is louder.
I was so bad at throwing and kicking balls that I was made fun of despite actually practicing both football and handball.
I went to sleep scared for a long time because I imagined people breaking in because of slightest squeek in the house.
It’s also hard to explain how easy it is to have conversations with other autistic people vs normies.
Fuck yeah, I’m tired of having to use the trackpad to move the mouse because my screen dimmed.
I feel like Wikipedia will be way better than explaining. I’ll put it here inside a spoiler tag. I don’t know a lot about this besides the basics so I won’t be able to do it justice. Fair to say it does a lot of stuff.
https://en.wikipedia.org/wiki/Serotonin
Digestive tract (emetic)
Serotonin regulates gastrointestinal (GI) function. The gut is surrounded by enterochromaffin cells, which release serotonin in response to food in the lumen. This makes the gut contract around the food. Platelets in the veins draining the gut collect excess serotonin. There are often serotonin abnormalities in gastrointestinal disorders such as constipation and irritable bowel syndrome.[75]
If irritants are present in the food, the enterochromaffin cells release more serotonin to make the gut move faster, i.e., to cause diarrhea, so the gut is emptied of the noxious substance. If serotonin is released in the blood faster than the platelets can absorb it, the level of free serotonin in the blood is increased. This activates 5-HT3 receptors in the chemoreceptor trigger zone that stimulate vomiting.[76] Thus, drugs and toxins stimulate serotonin release from enterochromaffin cells in the gut wall which can induce emesis. The enterochromaffin cells not only react to bad food but are also very sensitive to irradiation and cancer chemotherapy. Drugs that block 5HT3 are very effective in controlling the nausea and vomiting produced by cancer treatment, and are considered the gold standard for this purpose.[77]
Lungs
The lung,[78] including that of reptiles,[79] contains specialized epithelial cells that occur as solitary cells or as clusters called neuroepithelial bodies or bronchial Kulchitsky cells or alternatively K cells.[80] These are enterochromaffin cells that like those in the gut release serotonin.[80] Their function is probably vasoconstriction during hypoxia.[78]
Skin
Serotonin is also produced by Merkel cells which are part of the somatosensory system.[81]
Bone metabolism
In mice and humans, alterations in serotonin levels and signalling have been shown to regulate bone mass.[82][83][84][85] Mice that lack brain serotonin have osteopenia, while mice that lack gut serotonin have high bone density. In humans, increased blood serotonin levels have been shown to be a significant negative predictor of low bone density. Serotonin can also be synthesized, albeit at very low levels, in the bone cells. It mediates its actions on bone cells using three different receptors. Through 5-HT1B receptors, it negatively regulates bone mass, while it does so positively through 5-HT2B receptors and 5-HT2C receptors. There is very delicate balance between physiological role of gut serotonin and its pathology. Increase in the extracellular content of serotonin results in a complex relay of signals in the osteoblasts culminating in FoxO1/ Creb and ATF4 dependent transcriptional events.[86] Following the 2008 findings that gut serotonin regulates bone mass, the mechanistic investigations into what regulates serotonin synthesis from the gut in the regulation of bone mass have started. Piezo1 has been shown to sense RNA in the gut and relay this information through serotonin synthesis to the bone by acting as a sensor of single-stranded RNA (ssRNA) governing 5-HT production. Intestinal epithelium-specific deletion of mouse Piezo1 profoundly disturbed gut peristalsis, impeded experimental colitis, and suppressed serum 5-HT levels. Because of systemic 5-HT deficiency, conditional knockout of Piezo1 increased bone formation. Notably, fecal ssRNA was identified as a natural Piezo1 ligand, and ssRNA-stimulated 5-HT synthesis from the gut was evoked in a MyD88/TRIF-independent manner. Colonic infusion of RNase A suppressed gut motility and increased bone mass. These findings suggest gut ssRNA as a master determinant of systemic 5-HT levels, indicating the ssRNA-Piezo1 axis as a potential prophylactic target for treatment of bone and gut disorders. Studies in 2008, 2010 and 2019 have opened the potential for serotonin research to treat bone mass disorders.[87][88]
Organ development
Since serotonin signals resource availability it is not surprising that it affects organ development. Many human and animal studies have shown that nutrition in early life can influence, in adulthood, such things as body fatness, blood lipids, blood pressure, atherosclerosis, behavior, learning, and longevity.[89][90][91] Rodent experiment shows that neonatal exposure to SSRIs makes persistent changes in the serotonergic transmission of the brain resulting in behavioral changes,[92][93] which are reversed by treatment with antidepressants.[94] By treating normal and knockout mice lacking the serotonin transporter with fluoxetine scientists showed that normal emotional reactions in adulthood, like a short latency to escape foot shocks and inclination to explore new environments were dependent on active serotonin transporters during the neonatal period.[95][96]
Human serotonin can also act as a growth factor directly. Liver damage increases cellular expression of 5-HT2A and 5-HT2B receptors, mediating liver compensatory regrowth (see Liver § Regeneration and transplantation)[97] Serotonin present in the blood then stimulates cellular growth to repair liver damage.[98]
5-HT2B receptors also activate osteocytes, which build up bone[99] However, serotonin also inhibits osteoblasts, through 5-HT1B receptors.[100]
Cardiovascular growth factor
Main article: Cardiac fibrosis Serotonin, in addition, evokes endothelial nitric oxide synthase activation and stimulates, through a 5-HT1B receptor-mediated mechanism, the phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures.[clarification needed][101] In blood, serotonin is collected from plasma by platelets, which store it. It is thus active wherever platelets bind in damaged tissue, as a vasoconstrictor to stop bleeding, and also as a fibrocyte mitotic (growth factor), to aid healing.[102]
Adipose tissue
Serotonin also regulates white and brown adipose tissue function, and adipocytes are capable of producing 5-HT separately from the gut. Serotonin increases lipogenesis through HTR2A in white adipose tissue, and suppressed thermogenesis in brown adipose tissue via Htr3.[103]
Fun exception is endocannabinoids, giving you a runners high when running.
Endorphin doesn’t cross the barrier but morphine does, we basically find ways to sneak stuff into the brain.
It works both inside and outside, it just does something completely different when not in the brain.
That’s true, the gut and the brain are tightly linked and are in constant communication with each other, an obvious example is hunger for example.
I felt the need to comment this because serotonin and dopamine produced in the gut have completely different functions from the dopamine and serotonin in the brain. On top of that the body keeps those completely separate with the blood brain barrier so it can regulate those different functions individually.
The gut does play a part in tryptophan production and extraction which passes the blood brain barrier and the brain uses to make serotonin so the gut does affect serotonin levels. But that’s just “eat healthy, feel good” type of stuff.
I’m just not a fan of oversimplified version of this where people say “90-95% of serotonin is made in the gut, serotonin is the feel good hormone so gut affects happiness”. I mean, most people are aware that what you eat affects your mood but saying the gut is responsible for producing the hormones for the brain is just wrong when talking about dopamine and serotonin.
I feel like I’ll be prepared later on but I’m fully expecting to not be ready when the time comes.
I’m an autistic male and for me expressing myself in general is a bit awkward. During tough times I really liked expressing it to my friends and siblings since it’s a decent way to process the feelings.
YSK that this is just plain wrong for serotonin at least. Serotonin can’t cross the blood brain barrier.
This is such an immersion breaking aspect of modern games and an absolute garbage approach. They’re idea is to not break the “flow” for the action players but for players that like puzzles it’s absolute horror. They just need to add during new game a “Puzzle hints” menu with Normal, Low and None.
“That rock looks fragile”, “Have you seen the rock next to the windmill? It has cracks in it”, “What if we shoot the rock with the ballista?” at those points I just want a “Shut up” option.
If I can’t figure out the puzzle myself it removes all satisfaction from solving it. I want to be confused, open up a journal that I need to skim through to get relevant information and then put the pieces together.
nzb360 that I got a perpetual license for at 10eur. It’s so easy and convenient to torrent stuff for my Jellyfin.
Niagara launcher is free but I paid for the perpetual license. It’s a third party launcher that I really like.
I’m also a Jetbrains fan depending on the language, they have so much support for everything just out of the box and are on Linux.
Also games, but I guess people don’t want to hear those here. Factorio was definitely worth.
Could be solved that way, I personally don’t participate in it.
Don’t upgrade unless you’re going for motherboard, RAM and CPU upgrade.
Buying RAM today is pricey so I’m not sure if it’s possible to upgrade on a lean budget. A used combo of the three might be available though at a decent price.
That might be changing in the near future. Hybrid GPU work is currently being worked on a bunch.
And also the HDMI people since they don’t allow drivers that use their official specs to be open source. So to use HDMI 2.1 you have to install a proprietary closed source driver.
They could do it by having a post install blob add-on though so we can blame Nvidia for not putting in the effort.
I remember one game having the replacement mag taped to the current so it was an easy out flip in every time.