I think it would probably become “2X” in that case, given the “exploit” and “exterminate” parts. :P
Against the Storm is sort of a citybuilder/ 4X hybrid, that’s all about a bunch of fantasy species (humans, beavers, lizards, foxes, and harpies) working together to reclaim the world from this (un)natural blight.
The Bustling World is an RPG/ Citybuilder/ 4X hybrid that looks pretty interesting, but is not out yet.
I can’t really think of a 4X that leans towards the Grand Strategy side, that isn’t pretty combat-heavy. Distant Worlds: Universe can be played without focusing on combat, but it’s definitely still there.
Por que no los dos?
Reading further, it’s a pretty compelling argument that sanctions are the root cause, and this kind of instability and pressure is exactly what sanctions are meant to bring about.